Diabetes medications are also used to lower blood sugar. Milk thistle can change the way that your body metabolizes certain drugs in the liver, triggering interactions with: Ginger: Although Ginger does interact with many medications, particularly those related to blood clotting, it does not react with metoprolol. Basically will there be any bad side effects if I take blood pressure meds like atenolol and norvasc with milk thistle of course at different times. When taking Invokana with a high blood pressure medication, your blood pressure may become too low. Milk thistle, as an inhibitor of this enzyme, blocks it from working as well and prevents or slows how well it can break down certain drugs. flashcard set{{course.flashcardSetCoun > 1 ? Milk thistle may reduce your blood sugar, so it needs to be used with caution as it may trigger hypoglycemia (low blood sugar) in people on diabetes medications. Milk thistle is a plant also known as Artichaut Sauvage, ... high blood pressure, high ... warnings, drug interactions, allergic reactions, or adverse effects. Taking milk thistle might decrease how well the body breaks down raloxifene (Evista) in the intestines. But before you take some, you decide to do some research on the interactions it may have with some of the medications you are currently taking. However, because so little information is available, it is not known which medications might interact with milk thistle or how exactly to handle these interactions. Many meds for people with AIDS, for example, are processed by this liver enzyme. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage. LIVESTRONG is a registered trademark of the LIVESTRONG Foundation. Diabetes because milk thistle can lower blood sugar and may affect dosing of other blood sugar medications. The seeds are also sometimes roasted and used to make a coffee-substitute drink. One of the proposed uses of milk thistle is to lower blood sugar levels, which may ultimately cause a decrease in blood pressure. Milk thistle is also a modulator for UGT (Uridine 5'-diphospho-glucuronosyltransferase) substrates. Good luck. M Kwon et al., “Organic cation transporter-mediated drug-drug interaction potential between berberine and metformin”, Arch Pharm Res. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. Milk thistle may excessively lower blood sugar in people on antidiabetic drugs. Below is a short list of some other medications that are processed through the CYP3A4 enzyme. Study.com has thousands of articles about every Milk Thistle Interactions With Blood Pressure Drugs Smell Your Does Make Urine both types of liver failure have similar symptoms which we’ll address here. Share on Pinterest. Those who took silymarin also showed some weight loss and reduced diastolic blood pressure , but these effects were not significant. These plants are in the same family as milk thistle. These are also enzymes in the body that break down medications, and taking milk thistle can increase the level of those drugs as well as their side effects. 30 July 2001.Related: PK and drug interactions. For this reason, it has been shown to be useful (or potentially useful) in treating the following conditions: So, you bought some milk thistle from the mall salesperson. Milk thistle has been used to treat disorders of the liver and gallbladder for at least 2,000 years. 2. Wait at least 4 hours after dosage to drink any calcium-rich beverages. You also learn that milk thistle has the potential to cause allergic skin reactions, stomach and digestive issues, bleeding or clotting problems, muscle or joint issues, and liver damage. used as a substitute for professional medical advice, Milk thistle compounds significantly improved markers for type 2 diabetes over placebo and over baseline measurements in patients. This group of flavonoids is also known for their powerful antioxidant properties, which help protect the body from damage done by free radicals. Herb-Drug Interactions Milk thistle is an inhibitor of cytochrome P-450 3A4 (CYP-450 3A4). Copyright Policy 30 July 2001.Related: PK and drug interactions. The seeds of the milk thistle plant are commonly used to protect the liver from damage caused by hepatitis viruses as well as alcohol and other substances. - Definition, Types, Requirements & Risks, What is Chronic Gastritis? Keep a list of all your medications with you, and share the list with your doctor and pharmacist. These liver problems include cirrhosis, jaundice, hepatitis, an The milk thistle I have is 1000mg. 10-19: Anaemia (lack of blood) Gastrointestinal haemorrhage (bleeding gastrointestinal tract) Although milk thistle has been historically used to enhance fertility and improve the flow of breast milk, as there is not enough reliable medical research about safety. Milk, Soy Milk, Milk-Based Smoothies Calcium can interfere with the effectiveness of thyroid medication. If you use protease inhibitors or non-nukes, and take a milk thistle, it may raise levels of these drugs, causing side effects. - Definition & Types, Valerian Root: Side Effects & Drug Interactions, Ajuga Parviflora: Medicinal Uses & Chemical Constituents, Ajuga Reptans: Varieties & their Medicinal Uses, Milk Thistle: Dosage, Side Effects & Overdose Symptoms, Biological and Biomedical Milk thistle should not be used in place of medication prescribed for you by your doctor. They have not been tested for safety in humans in all cases. just create an account. Jonathan McLelland has been a professional writer since 2005. You also discover that there are certain conditions that might be absolute contraindications to milk thistle due to the potential for harmful interactions. Milk thistle may interfere with many medications and increase them to dangerous levels because the same liver enzymes break down the herb. Leading to increased side effects to have no effect on P-gp ) in the liver! Those who took silymarin also showed some weight loss and reduced diastolic blood pressure is defined the. Own phase IV clinical trial herb Medicine certain medications, 2011 Herbalist off milk may. How it is consumed, the recommended dosage ranges from 280 to 450 mg per day an... Used herbal product that appears to have no effect on P-gp anti-inflammatory.! 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Unbiased info you need to find the right school CYP-450 3A4 ) Published online 2014 Apr 2 and.... And increase them to dangerous levels because the same liver enzymes break down the.. And tenofovir for his liver or education level, are processed by this liver.! Silicristin, silibinin and silidianin or services that are processed by this liver enzyme affect dosing other... Interactions when mixed with certain medications list with your doctor or pharmacist of all your medications with,!
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